Nicolas Cage
John Cusack
John Malkovich
Ving Rhames
Nick Chinlund
Steve Buscemi
Colm Meaney
Rachel Ticotin
Dave Chappelle
Mykelti Williamson
Nicolas Cage as Cameron Poe
John Cusack as U.S. Marshal Vince Larkin
John Malkovich as Cyrus 'The Virus' Grissom
Ving Rhames as Nathan 'Diamond Dog' Jones
Nick Chinlund as William 'Billy Bedlam' Bedford
Steve Buscemi as Garland 'The Marietta Mangler' Greene
Colm Meaney as DEA Agent Duncan Malloy
Rachel Ticotin as Guard Sally Bishop
Dave Chappelle as Joe 'Pinball' Parker
Mykelti Williamson as Mike 'Baby-O' O'Dell
Danny Trejo as Johnny 'Johnny-23' Baca
M.C. Gainey as Swamp Thing
Steve Eastin as Guard Falzon
Renoly Santiago as Ramon 'Sally-Can't Dance' Martinez (as Renoly)
Monica Potter as Tricia Poe