Roy Scheider
John Lithgow
Helen Mirren
Bob Balaban
Keir Dullea
Douglas Rain
Madolyn Smith Osborne
Dana Elcar
Taliesin Jaffe
James McEachin
Roy Scheider as Dr. Heywood Floyd
John Lithgow as Dr. Walter Curnow
Helen Mirren as Tanya Kirbuk
Bob Balaban as Dr. R. Chandra
Keir Dullea as Dave Bowman
Douglas Rain as HAL 9000 (voice)
Madolyn Smith Osborne as Caroline Floyd (as Madolyn Smith)
Dana Elcar as Dimitri Moisevitch
Taliesin Jaffe as Christopher Floyd
James McEachin as Victor Milson
Mary Jo Deschanel as Betty Fernandez, Bowman's Wife
Elya Baskin as Maxim Brajlovsky
Saveli Kramarov as Dr. Vladimir Rudenko (as Savely Kramarov)
Oleg Rudnik as Dr. Vasili Orlov
Natasha Shneider as Irina Yakunina