Roberto Benigni
Steven Wright
Joie Lee
Cinqué Lee
Steve Buscemi
Iggy Pop
Tom Waits
Joseph Rigano
Vinny Vella
Vinny Vella Jr.

Roberto Benigni as Roberto (segment "Strange to Meet You")
Steven Wright as Steven (segment "Strange to Meet You")
Joie Lee as Good Twin (segment "Twins")
Cinqué Lee as Evil Twin/Kitchen Guy (segment "Twins/Jack Shows Meg His Tesla Coil")
Steve Buscemi as Waiter (segment "Twins")
Iggy Pop as Iggy (segment "Somewhere in California")
Tom Waits as Tom (segment "Somewhere in California")
Joseph Rigano as Joe (segment "Those Things'll Kill Ya") (as Joe Rigano)
Vinny Vella as Vinny (segment "Those Things'll Kill Ya")
Vinny Vella Jr. as Vinny Jr. (segment "Those Things'll Kill Ya")
Renee French as Renée (segment "Renée") (as Renée French)
E.J. Rodriguez as Waiter (segment "Renée")
Alex Descas as Alex (segment "No Problem")
Isaach De Bankolé as Isaach (segment "No Problem")
Cate Blanchett as Cate/Shelly (segment "Cousins")