David Duchovny
Julianne Moore
Orlando Jones
Seann William Scott
Ted Levine
Ethan Suplee
Michael Bower
Pat Kilbane
Ty Burrell
Dan Aykroyd
David Duchovny as Dr. Ira Kane
Julianne Moore as Dr. Allison Reed, CDC
Orlando Jones as Prof. Harry Phineas Block
Seann William Scott as Wayne Grey
Ted Levine as General Russell Woodman
Ethan Suplee as Deke
Michael Bower as Danny (as Michael Ray Bower)
Pat Kilbane as Officer Sam Johnson
Ty Burrell as Colonel Flemming
Dan Aykroyd as Governor Lewis
Katharine Towne as Nadine
Gregory Itzin as Barry Cartwright
Ashley Clark as Lieutenant Cryer
Michelle Wolff as Carla
Sarah Silverman as Denise