Dan Aykroyd
Kim Basinger
Jon Lovitz
Alyson Hannigan
Joseph Maher
Seth Green
Ann Prentiss
Wesley Mann
Tony Jay
Peter Bromilow
Dan Aykroyd as Steven Mills
Kim Basinger as Celeste Martin
Jon Lovitz as Ron Mills
Alyson Hannigan as Jessie Mills
Joseph Maher as Lucas Budlong
Seth Green as Fred Glass
Ann Prentiss as The Bag (voice)
Wesley Mann as Grady
Tony Jay as Council Chief
Peter Bromilow as Second in Command
Nina Henderson as Cashier
Harry Shearer as Carl Sagan (voice)
Adrian Sparks as Dr. Morosini
Juliette Lewis as Lexie, Jessie's Friend #1
Tanya Fenmore as Ellen, Jessie's Friend #2