Robert B. Weide
Cheryl Hines
Jeff Garlin
Susie Essman
Richard Lewis
Shelley Berman
Antoinette Spolar
Al Whiting
Ashly Holloway
Ted Danson
Robert B. Weide as Himself (51 episodes, 2000-2007)
Cheryl Hines as Cheryl David (46 episodes, 2000-2007)
Jeff Garlin as Jeff Greene (44 episodes, 2000-2007)
Susie Essman as Susie Greene (26 episodes, 2000-2007)
Richard Lewis as Himself (18 episodes, 2000-2007)
Shelley Berman as Nat David (11 episodes, 2002-2005)
Antoinette Spolar as Larry's Receptionist / ... (11 episodes, 2000-2004)
Al Whiting as Orderly (10 episodes, 2005)
Ashly Holloway as Sammy Greene / ... (9 episodes, 2001-2007)
Ted Danson as Himself (8 episodes, 2000-2007)
Paul Dooley as Cheryl's Dad (7 episodes, 2000-2005)
Julie Payne as Cheryl's Mom (7 episodes, 2000-2005)
Wanda Sykes as Wanda (7 episodes, 2001-2005)
Carla Jeffrey as Keisha / ... (6 episodes, 2007)
Suzy Nakamura as Assistant Manager (5 episodes, 2002)