Drew Barrymore
Piper Perabo
Andy Garcia
George Lopez
Cheech Marin
Paul Rodriguez
Plácido Domingo
Edward James Olmos
Loretta Devine
Jamie Lee Curtis
Drew Barrymore as Chloe (voice)
Piper Perabo as Rachel Ashe Lynn
Andy Garcia as Delgado (voice)
George Lopez as Papi (voice)
Cheech Marin as Manuel (voice)
Paul Rodriguez as Chico (voice)
Plácido Domingo as Monte (voice)
Edward James Olmos as Diablo (voice)
Loretta Devine as Delta (voice)
Jamie Lee Curtis as Aunt Viv
Luis Guzmán as Chucho (voice)
Eddie 'Piolin' Sotelo as Rafa (voice)
Carlos Juvera as Tomás (voice)
Alex Mendoza as Frightened Terrier / Gang Leader Bull Dog (voice)
Lombardo Boyar as Praying Dog