Adrien Brody
Jeffrey Wright
Gabrielle Union
Columbus Short
Cedric the Entertainer
Emmanuelle Chriqui
Eamonn Walker
Mos Def
Beyonce Knowles
Tim Bellow
Adrien Brody as Leonard Chess
Jeffrey Wright as Muddy Waters
Gabrielle Union as Geneva Wade
Columbus Short as Little Walter
Cedric the Entertainer as Willie Dixon
Emmanuelle Chriqui as Revetta Chess
Eamonn Walker as Howlin' Wolf
Mos Def as Chuck Berry
Beyonce Knowles as Etta James
Tim Bellow as Man in the Caddy
Tony Bentley as Lomax
Lawrence P. Beron as Overseer
Tammy Blanchard as Isabelle Allen
Eric Bogosian as Alan Freed
Marc Bonan as Keith Richards