John C. Reilly
Jonah Hill
Marisa Tomei
Catherine Keener
Matt Walsh
Diane Mizota
Kathy Wittes
Katie Aselton
Jamie Donnelly
Tim Guinee

John C. Reilly as John
Jonah Hill as Cyrus
Marisa Tomei as Molly
Catherine Keener as Jamie
Matt Walsh as Tim
Diane Mizota as Thermostat Girl
Kathy Wittes as Ashley (as Kathy Ann Wittes)
Katie Aselton as Pretty Girl (as Kathryn Aselton)
Jamie Donnelly as Pastor
Tim Guinee as Roger
Charlie Brewer as Stranger at Reception
Steve Zissis as Rusty
Newell Alexander as Additional Voices (voice)
Steve Alterman as Additional Voices (voice)
Mitch Carter as Additional Voices (voice)