James Marsden
Russell Brand
Kaley Cuoco
Hank Azaria
Gary Cole
Elizabeth Perkins
Hugh Laurie
Tiffany Espensen
David Hasselhoff
Chelsea Handler
James Marsden as Fred O'Hare
Russell Brand as E.B. / Production Assistant (voice)
Kaley Cuoco as Sam O'Hare
Hank Azaria as Carlos / Phil (voice)
Gary Cole as Henry O'Hare
Elizabeth Perkins as Bonnie O'Hare
Hugh Laurie as E.B.'s Dad (voice)
Tiffany Espensen as Alex O'Hare
David Hasselhoff as Himself
Chelsea Handler as Mrs. Beck
Dustin Ybarra as Cody
Carlease Burke as Receptionist
Veronica Alicino as Waitress
Django Marsh as Young E.B. (voice)
Jimmy Carter as Blind Boys of Alabama (as Jimmy Lee Carter)