Michael J. Fox
Geena Davis
Hugh Laurie
Jonathan Lipnicki
Nathan Lane
Chazz Palminteri
Steve Zahn
Jim Doughan
David Alan Grier
Bruno Kirby

Michael J. Fox as Stuart Little (voice)
Geena Davis as Mrs. Eleanor Little
Hugh Laurie as Mr. Fredrick Little
Jonathan Lipnicki as George Little
Nathan Lane as Snowbell 'Snow', the Little's house-cat (voice)
Chazz Palminteri as Smokey, the Chief Alley-Cat (voice)
Steve Zahn as Monty the Mouth (voice)
Jim Doughan as Detective Allen/Voice of Lucky (Alley Cat)
David Alan Grier as Red (Alley Cat) (voice)
Bruno Kirby as Mr. Reginald 'Reggie' Stout (voice)
Jennifer Tilly as Mrs. Camille Stout (voice)
Stan Freberg as Race Announcer (voice)
Jeffrey Jones as Uncle Crenshaw Little
Connie Ray as Aunt Tina Little
Allyce Beasley as Aunt Beatrice Little