Bob Hoskins
Christopher Lloyd
Joanna Cassidy
Charles Fleischer
Stubby Kaye
Alan Tilvern
Richard LeParmentier
Lou Hirsch
Betsy Brantley
Joel Silver
Bob Hoskins as Eddie Valiant
Christopher Lloyd as Judge Doom
Joanna Cassidy as Dolores
Charles Fleischer as Roger Rabbit/Benny The Cab/Greasy/Psycho (voice)
Stubby Kaye as Marvin Acme
Alan Tilvern as R.K. Maroon
Richard LeParmentier as Lt. Santino (as Richard Le Parmentier)
Lou Hirsch as Baby Herman (voice)
Betsy Brantley as Jessica's Performance Model
Joel Silver as Raoul (Director)
Paul Springer as Augie
Richard Ridings as Angelo
Edwin Craig as Arthritic Cowboy
Lindsay Holiday as Soldier
Mike Edmonds as Stretch