Michael J. Fox
Geena Davis
Hugh Laurie
Jonathan Lipnicki
Anna Hoelck
Ashley Hoelck
Nathan Lane
Melanie Griffith
James Woods
Steve Zahn
Michael J. Fox as Stuart Little (voice)
Geena Davis as Mrs. Eleanor Little
Hugh Laurie as Mr. Frederick Little
Jonathan Lipnicki as George Little
Anna Hoelck as Martha Little
Ashley Hoelck as Martha Little
Nathan Lane as Snowbell (voice)
Melanie Griffith as Margalo the Bird (voice)
James Woods as The Evil Falcon (voice)
Steve Zahn as Monty the Alley-Cat (voice)
Marc John Jefferies as Will, George's Friend
Angelo Massagli as Wallace
Jim Doughan as Soccerball Coach
Brad Garrett as Plumber
Conan McCarty as Referee