Hilary Duff
Adam Lamberg
Hallie Todd
Robert Carradine
Jake Thomas
Ashlie Brillault
Clayton Snyder
Alex Borstein
Yani Gellman
Brendan Kelly

Hilary Duff as Lizzie McGuire/Isabella Parichi
Adam Lamberg as David Zephyr "Gordo" Gordon
Hallie Todd as Jo McGuire
Robert Carradine as Sam McGuire
Jake Thomas as Matthew "Matt" McGuire
Ashlie Brillault as Kate Sanders
Clayton Snyder as Ethan Craft
Alex Borstein as Miss Ungermeyer
Yani Gellman as Paolo Valisari
Brendan Kelly as Sergei
Carly Schroeder as Melina Bianco
Daniel Escobar as Mr. Escobar (as Daniel R. Escobar)
Jody Racicot as Giorgio
Peter Kelamis as Dr. Comito
Terra C. MacLeod as Franca DiMontecatini