Eddie Murphy
Randy Quaid
Rosario Dawson
Joe Pantoliano
Jay Mohr
Luis Guzmán
James Rebhorn
Peter Boyle
Burt Young
Miguel A. Núñez Jr.
Eddie Murphy as Pluto Nash
Randy Quaid as Bruno
Rosario Dawson as Dina Lake
Joe Pantoliano as Mogan
Jay Mohr as Tony Francis
Luis Guzmán as Felix Laranga
James Rebhorn as Belcher
Peter Boyle as Rowland
Burt Young as Gino
Miguel A. Núñez Jr. as Miguel
Pam Grier as Flura Nash
John Cleese as James
Victor Varnado as Kelp
Illeana Douglas as Dr. Mona Zimmer
Jacynthe René as Babette