John Goodman
Kelly McGillis
Trini Alvarado
Bruce Boxleitner
Peter Donat
James Cromwell
J.C. Quinn
Joe Ragno
Richard Tyson
Ralph Marrero
John Goodman as George Herman 'Babe' Ruth
Kelly McGillis as Clare Hodgson Ruth
Trini Alvarado as Helen Woodford Ruth
Bruce Boxleitner as Jumpin' Joe Dugan
Peter Donat as Harry Frazee
James Cromwell as Brother Mathias
J.C. Quinn as Jack Dunn
Joe Ragno as Miller Huggins
Richard Tyson as Guy Bush
Ralph Marrero as Ping
Robert Swan as George Ruth Sr. (as Bob Swan)
Bernard Kates as Colonel Jack Ruppert
Michael McGrady as Lou Gehrig
Stephen Caffrey as Johnny Sylvester
Gene Ross as Brother Paul